Appel studied at the Rijksakademie van Beeldende Kunsten in Amsterdam during the German Occupation from 1940 to 1943 and it was there he met the young painterCorneille and, some years later, Constant; they became close friends for years. His parents opposed his choice to become an artist, leading him to leave home; this was also necessary because he needed to hide from the German police so that he would not be picked up and sent to Germany to work in the weapon industry. Appel had his first show in Groningen in 1946. In 1949 he participated with the other CoBrA artists in the Stedelijk Museum Amsterdam; this generated a huge scandal and many objections in the press and public. He was influenced by Pablo Picasso, Henri Matisse and the French brute-art artist Jean Dubuffet. In 1947 he started sculpting with all kinds of used materials (in the technique of assemblage) and painted them in bright colors: white, red, yellow, blue and black. He joined the Experimentele Groep in Holland together with the young Dutch painters Anton Rooskens, Theo Wolvecamp and Jan Nieuwenhuys. Later the Belgian writer Hugo Claus joined the group.
In 1948 Appel joined CoBrA (from:Copenhagen, Bruxelles, Amsterdam) together with the Dutch artists Corneille, Constant and Jan Nieuwenhuys (see also Aart Kemink) and with the Belgian poet Christian Dotremont. The new art of the CoBrA-group was not popular in the Netherlands, but it found a warm and broad welcome in Denmark. By 1939, Danish artists had already started to make spontaneous art and one of their sources of inspiration was Danish and Nordic mythology. It was also in Denmark that the CoBrA artists started cooperating by collectively painting the insides of houses, which encouraged and intensified the exchange of the typical 'childish' and spontaneous picture language used by the CoBrA group. Appel used this very intensively; his 1949 fresco 'Questioning Children' in Amsterdam City Hall caused controversy and was covered up for ten years.
As a result of this controversy and other negative Dutch reactions to CoBrA, Appel moved to Paris in 1950 and developed his international reputation by travelling toMexico, the USA, Yugoslavia and Brazil. He is particularly noted[by whom?] for his mural work and lived in New York and Florence. After 1990 he became much more popular in the Netherlands; he had several big shows in Amsterdam and in Bruxelles, organized by director Rudy Fuchs. Also the CoBrA-museum in Amstelveen organized several shows with his work. He became the most famous Dutch artist of CoBrA.